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Resveratrol prevents antibodyinduced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70

In addition, the hyperactivated PI3K/Akt/mTOR signaling pathway is strongly inhibited, collectively disrupting the inflammatory, vascular, and proliferative mechanisms that support EMs persistence ( In vitro studies using aged human dermal fibroblasts, a validated model of mitochondrial aging, show that the spirulina polysaccharide complex (SPC) markedly upregulates the mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2), increasing both its transcriptional expression and enzymatic activity