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In randomized, double-blind controlled clinical trials comparing ciprofloxacin tablets [500 mg two times daily (BID)] to cefuroxime axetil (250 mg500 mg BID) and to clarithromycin (500 mg BID) in patients with respiratory tract infections, ciprofloxacin demonstrated a CNS adverse reaction profile comparable to the control drugs

It should be noted that not only high glucose concentrations, but also toxic constituents of cigarette smoke might induce glycotoxins that rapidly react with protein to form AGE 6