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Moreover, Exercise intervention not only downregulates lipid peroxidation-related factors acyl-CoA synthetase long-chain family member 4 (ACSL4) and arachidonate 15-lipoxygenase (ALOX15), but also concurrently activates the Xc/GPX4 axis to suppress PUFA oxidation, thereby interrupting the ferroptotic cascade in male C57BL/6 J mice [103]