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In this framework, an extensive search of the literature was carried out beginning with the scientific and governmental data platforms

HepG2 cells exhibited higher catalase activity than HeLa cells, and inhibiting catalase activity by using 3-aminotriazole (3-AT, a specific inhibition of catalase) or catalase siRNA remarkably reduced the resistance of HepG2 cells to ROS, demonstrating the key roles of catalase for the strong resistance of HepG2 cells to ROS

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The complexity of this relationship stems from the multifaceted influence these amino acids exert on mitochondrial processes [38]