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As all cells in the body require cobalamin for single carbon metabolism, it has been hypothesized that cobalamin deficiency may actually contribute to the clinical signs and manifestations of gastrointestinal disease in some patients
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(PMID: 15531385), rats given BPC-157 0.0045 mg/lb showed significantly elevated serotonin synthesis in the substantia nigra reticulata and medial anterior olfactory nucleus following acute administration
But 'normalizing' can feel very different depending on the starting point of the biological system in question
