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Additionally, the heat shock transcription factor 1 (HSF1) binds to symplekin upon heat shock and this interaction may promote the mRNA 3 processing of heat shock protein genes 50

PMID: 35944649 Bioorg Chem A novel ER-targeted hydrophobic tag degrader, overcomes tamoxifen resistance via unfolded protein response-induced apoptosis and homologous recombination repair inhibition in breast cancer