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Its a question many people are asking, given the fact that B12 is so dramatically effective in individuals who are truly B12 deficient, says Ralph Green, M.D., Ph.D., FRC Path, a distinguished professor and emeritus chair in the department of pathology and laboratory medicine at U.C

Studies show the consuming an excessive amount of vitamin B12 may: Increase the risk of cardiovascular events in people with diabetic nephropathy : A study published in JAMA sought to determine whether B vitamin therapy was able to slow the progression of diabetic nephropathy (kidney damage due to diabetes) and prevent vascular complications

It resists breakdown by gastric acid, a property tied to the sequence itself

Safdar says he knows of several instances when people had serious health problems after taking compounded medications