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Probiotic induction of mucin secretion offers not only a shield over the gut lining itself but also immune-modulating effects, therefore overall enhancement of gut health (67, 73, 74), or by interacting with specific receptors, which further stimulate the release of antimicrobial peptides or increase tight junction protein expression (53, 75, 76)

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GXP4 knock-out in mice results in embryonic lethality, indicating its unique role and limited number of pathways involved in cellular protection from lipid hydroperoxides

Mouse liver was perfused with Hanks balanced salt solution (HBSS, Thermo Fisher, MA, USA) without Ca 2+ & Mg 2+ and containing 0.5 mM EGTA (Sigma, MO, USA) for 5 min through the portal vein