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Researchers suspected that nicotine exposure might increase vulnerability to cocaine

What is so exciting about our study is that it shows that its never too late to quit some of the people in our study had smoked more than 15,000 packs of cigarettes over their life, but within a few years of quitting many of the cells lining their airways showed no evidence of damage from tobacco. Smoking causes up to 10,000 extra mutations in nine out of every 10 lung cells, the researchers found, including many that cause cancer

Smoking also upregulated pathways related to amino acid and nucleotide sugar metabolism