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Numerous studies have shown that Nrf2 activation can effectively suppress the NF-B signalling pathway, thereby hindering the activation of inflammatory factors, mitigating the inflammatory response, and influencing the onset and progression of RA [112,113,114]

CA may inhibit the expression of these genes and exert anti-RA effects by acting on nitrogen metabolism, estrogen signaling pathway, RAS-associated protein 1 (Rap1) signaling pathway, PI3K/Akt signaling pathway, etc

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