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Additionally, DSIP appears to be regulated by glucocorticoids, and its signaling may interact with the MAPK cascade through homology with glucocorticoid-induced leucine zipper (GILZ), suggesting potential roles in cellular stress responses

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These problems occur when the body is not capable of properly utilising vitamin B12, leaving it to accumulate in the blood

Hence, arthritis only developed in mice, which developed increased intestinal permeability (based on lactulose/mannitol ratio measurements) and intestinal inflammation (based on small intestine length measurement) (Fig