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Together they reduce binding affinity to the six IGF binding proteins (IGFBP-1 through IGFBP-6) by approximately one to two orders of magnitude, while preserving full agonist activity at the type 1 IGF receptor

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Specifically, the proportion of Firmicutes is markedly reduced, the Bacteroidetes-to-Firmicutes ratio is decreased, and the abundance of Acidobacteria is increased (Soltysova et al., 2022)