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122 In a randomized controlled trial in 44 men with infertility, 25 mg lycopene daily for 12 weeks led to greater improvements in sperm count, concentration, motility, and morphology, as well as increased semen volume and decreased semen oxidative stress, compared with placebo

Parnis FX, Coleman RE, Harper PG, et al

Hassan and emlika 2016)

Annotating genes of interest First, we performed a literature review of all genes within 500 kb of the 29 signals to identify genes with a reported link to one of the following four processes: (1) reproductive function, (2) steroid metabolism and sex-hormone levels, (3) pathways related to metabolic syndrome and (4) DNA damage repair, selected due to reported links between PCOS and age at menopause for which DNA damage repair is the dominant process 7