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aureus survives antibiotic treatment inside mammalian cells, C57BL/6J mice were infected via tail vein (i.v.) with the reporter strains and treated with 10 mg kg 1 rifampicin intraperitoneally (i.p.) at 1 day post infection (dpi)

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These findings suggest that research into the therapeutic modulation of FOXO4 activity, such as through the use of the synthetic peptide FOXO4-DRI, could provide insight into the heart's natural protective mechanisms and degenerative changes associated with aging