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Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )

PMID: 41298718 Sci RepCrocetin curbs radiation induced intestinal injury by blocking KAT2A/NLRP3 succinylation

Therapeutic protection against cyclophosphamide-induced ovarian injury in experimental studies Buspirone Buspirone (BUS) is a medication frequently prescribed for anxiety and depression, Functioning as a partial agonist at 5-HTA receptors and an antagonist at dopamine D receptors through presynaptic modulation of serotonin release (Loane and Politis 2012

Acetyl Hexapeptide-8: Pal-GHK targets structural aging (collagen loss) while AH-8 addresses dynamic wrinkles (muscle activity), making them complementary