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doi: 10.3389/fphys.2021.680544 Received 14 March 2021 Accepted 20 August 2021 Published 17 September 2021 Volume 12 - 2021 Edited by Karina Thieme, University of So Paulo, Brazil Reviewed by Nilberto Robson Falco Nascimento, State University of Cear, Brazil

Specifically, in an experimental model of GSH-Cu(I), the formation of the tetranuclear [Cu 4 (GS) 6 ] cluster was observed as the major species within the range of pH from 5.5 to 7.5 [175]

Notably, in models of type 2 diabetes, PCs confer neuroprotection by modulating NF-E2/STAT1 signaling, attenuating Janus kinase activity, and inhibiting cell apoptosis, thereby reducing cerebrovascular lesions and associated neurological deficits (Wu et al., 2015

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