[4] At the cellular level, free estradiol diffuses through cell membranes and binds to intracellular estrogen receptors and , which upon ligand activation dimerize and translocate to estrogen-response elements on nuclear DNA, modulating transcription of genes governing reproductive tract integrity, thermoregulation, bone metabolism, and vascular endothelial function
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It assumes the vial has been consistently stored at the correct temperature
Your practitioner will review your symptoms, medical history, and any relevant test results before recommending an appropriate treatment protocol