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Zagon IS, Mclaughlin PJ (2017) Endogenous opioids in the etiology and treatment of multiple sclerosis

Mechanistic Novelty Dihexa and Cerebrolysin are not direct competitors they occupy entirely different tiers of the evidence hierarchy, and comparing them reveals more about the drug development process than about relative efficacy

Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans