NAM, a metabolite in the salvage pathway, is reduced in both CSF and serum from ALS patients compared with healthy people
Ferroptosis can be triggered by GSH depletion, which can be achieved by inhibiting GSH biosynthesis (e.g., buthionine sulfoximine (BSO) inhibits -glutamylcysteine synthetas (-GCS)) or blocking the uptake of cysteine from the extracellular environment (e.g., erastin inhibits the Xc system) [126, 127]
895 , 896 , 897 As one example of collaborative dementia care, the Alzheimer's and Dementia Care Program is a health systemsbased model in which nurse practitioners with extensive training in dementia care, known as dementia care specialists (DCSs), comanage care with PCPs and communitybased partners
All images are intended for educational purposes only