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ET-1 reduces NO bioavailability and influences endothelial function directly by both reducing eNOS expression [64, 73] and activity, and by activating the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, a superoxide producing enzyme located in vascular cells and inflammatory cells such as macrophages [2, 67, 84]

Highly favored in European consumer preference studies, it is considered ideal for subtle flavour perception and all-day smoking ease, appealing to those who view smoking as a gentler ritual