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Mark Krause, the labs jovial, broad-shouldered director, walked me past dishwasher-size chromatography and mass-spectrometry machines

IIV, interindividual variability

Activated PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which functions as a second messenger, recruiting AKT and PDK1 to the plasma membrane