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Rezamahaleh FA, Khadivzadeh T, Asgharinekah SM, Esmaeili H

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683 Remarkably, the work summarized here on the superoxide dismutases (SODs) and ribonucleotide reductases (RNRs) reveal that cambialism and more generally metalloenzyme paralogs have evolved in enzymes that catalyze more restrictive chemistry, where a change in oxidation state and even access to high-valent intermediates, is involved

High IGF-1 levels, often caused by exogenous HGH use, can increase cancer risk, water retention, and insulin resistance