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Transl Psychiatry 15 , 65 (2025)

These results suggested that the HPA axis may be stimulated by increased inflammatory signaling and T-cell activation in MDD, which could subsequently result in immunosuppressive effects, as detected by the LPA test [14]

Currently, targeted neuroprotective drugs acting on ferroptosis pathways are under progressive development, with iron chelators, antioxidants, and free radical scavengers being extensively investigated to achieve neuronal protection through modulation of ferroptosis processes (224)