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(II) the potential role of amino acid metabolites (e.g., -ketoglutarate) in regulating iron-related gene expression through epigenetic modifications

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Following chronic liver injury, HSCs proliferate, lose their vitamin A and undergo a major phenotypical transformation to -smooth muscle actin (-SMA) positive activated HSCs, which produce a wide variety of collagenous and non-collagenous extracellular matrix (ECM) proteins [168]

The improved water-holding capacity in agricultural soils could be included as a sustainable agricultural strategy able to mitigate the negative impacts of drought conditions