Antioxid Redox Signal 2:665671 Savaskan NE, Heckl A, Hahnen E, Engelhorn T, Doerfler A, Gansladt O et al (2008) Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
(GSSG is a special case of a glutathione S -conjugate.) In addition to the kidney route for metabolism of leukotrienes mentioned earlier, hepatobiliary transport also occurs, and this is mediated by the GS-X pump (Ishikawa, 1993)
Additionally, neural repression of the KCC2 could affect synaptic maturation, compromising the function of inhibitory cortical neurons (Yeo et al., 2013)
Financial strategies: Prioritize most evidence-based peptides (Cerebrolysin for glaucoma, Thymosin Beta-4 for corneal issues), use loading dose then reduce to maintenance lowering long-term costs, cycle peptides (8 weeks on, 8 weeks off) versus continuous use, combine with well-established supplements (AREDS2) providing proven value, budget realistically understanding $100-$500 monthly ongoing expense, discontinue if financial burden excessive, focus resources on conventional treatments if limited budget
