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Early-stage organoids (Day 7) exhibited a proteomic profile characteristic of hepatoblast-like populations, marked by high levels of stem cell-associated transcription factors such as hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead box protein A2 (FOXA2) (Fig

Decades of preclinical and limited clinical research suggest that DSIP may enhance slow-wave sleep, support neuroendocrine function, and offer protective effects in certain physiological contexts, including post-stroke recovery and age-related cellular stress

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Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats