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Reduced glutathione can be prepared by chemical synthesis, but is usually produced by fermentation or biotransformation using various microbial strains, grown in suitable fermentation media containing the amino acids glutamic acid, cysteine and glycine, which serve as precursors

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Since most euthyroid and hypothyroid patients with orbitopathy are thyrotropin receptor antibody (TRAb)-positive, they are diagnosed as having euthyroid Graves disease or hypothyroid Graves disease