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28 29 Little is known about the consequences of maternal vitamin B 12 deficiency for early brain myelination, neurodevelopment and cognitive function

Concomitant use with central nervous-system depressants (e.g., benzodiazepines, barbiturates, opioids) could enhance sedation or respiratory depression

This distinction affects safety, regulation, and side effects

The results of a sequential supplementation trial in 53 men and women indicated that after optimization of folate status with folic acid supplements, vitamin B 12 became the major determinant of plasma homocysteine levels (30)