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Description

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

Zhang J, Chen Y, Li H, Li H

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321 Although Selonsertib led to dose-dependent reductions in hepatic levels of phosphorylated p38, an indicator of its pharmacodynamic activity, it does not have a significant effect on liver biochemistry, non-invasive tests of fibrosis, progression to cirrhosis, or adjudicated clinical events, probably due to the advanced fibrosis onset in these patients