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Subsequent choices of interface parameters and functional module combinations are, in essence, concrete routes through which these overarching aims are pursued, and they form the basis for the design logic outlined in the following subsections [9, 31, 33, 37]

Specifically, the uncontrolled release of pro-inflammatory cytokines such as IL-1, IL-6, and TNF- leads to myocardial depression, endothelial dysfunction, and triggers apoptosis pathways in cardiac cells 51

We believe continued expansion into healthy aging is critical to sustaining that trajectory and to fulfilling our mission: to empower everyone, everywhere to live better longerevery day

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