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(PubMed) Garone C, Donati MA, Sacchini M, et al

PARPs are most commonly known for DNA repair, although they also function in transcription, cell cycle regulation, and proteasome regulation 7

We believe that this limited contribution and non-essentiality of caspase-3 for the execution of eryptosis is associated with the absence of the upstream mitochondrial pathways in mature erythrocytes linked with the expulsion of this particular organelle at the terminal stages of erythropoiesis, as well as downstream effectors