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Fasting also induces many additional mechanisms that may be beneficial in neurodegenerative disorders, including the generation of ketones, increased expression of neurotrophic factors, and the stimulation of mitogenesis and mitophagy

Several metabolomics studies have confirmed that APAP-induced mitochondrial oxidative stress disrupted the metabolic processes of citric acid cycle and fatty acid -oxidation, thus blocking ATP synthesis and accelerating hepatocyte death

Patterns of pain medication usage and self-reported pain in older Irish adults with osteoarthritis: a latent class analysis of data from the Irish Longitudinal Study on Ageing

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