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Ramagopalan et al., 2008), which also implies that identical twins are discordant for MS in 75% of cases

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Specific concepts that we believe may be particularly noteworthy include: (1) Misfolding of innate CNS proteins, which then leads to their aggregation into potentially toxic oligomers or amyloids, leading to a toxic gain-of-function via numerous mechanisms including membrane disruption (Kandel et al., 2017

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