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It seems that this form is more abundant in tumour cells than in normal counterparts and that nuclear t-HO-1 correlates with clinical pathological features such as tumour grade and patient survival time [93]

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Impact of hydroxyurea treatment on the plasma metabolome Of the 433 patients with SS genotypes enrolled in this study, 306 had not been recently transfused (HbA 105 ( Online Supplementary Figure S2F ), owing to the well-established effect on this hematological parameter of hydroxyurea treatments