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To obtain orthogonal proof that our inhibitors bind to the NADP + -TGR(H) forms, we evaluated their effect on thermal stability of TGR using the thermal shift assay (TSA or differential scanning fluorometry)

For example, hepatocytes contain high levels of alpha GST and serum alpha GST has been found to be an indicator of hepatocyte injury in transplantation, toxicity and viral infections

doi: 10.1084/jem.177.4.1105 283 MukherjeeJ.FeldmesserM.ScharffM

Indeed, increased levels of proinflammatory cytokines, including IL-6, IL-1, IL-17A, and IL-22, are observed in psoriasis, leading to excessive ROS generation from both endogenous and exogenous sources, resulting in increased oxidative stress