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It modulates gene expression linked to tissue remodeling and exerts antioxidant and anti-inflammatory effects through TGF- and metalloproteinase regulation

The nanoparticle coating itself acts as an adjuvant that likely contributes to local reactions, Fuller adds

10.1016/0039-128X(94)00039-F 222

IV NAD delivers the coenzyme directly into the bloodstream, bypassing digestion and achieving concentrations that oral supplements cannot reliably produce