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Abbreviations CNT: Carbon nanotube GO: Graphene oxide MTM: Mini traction machine LBL: Layer by layer XRD: X-ray diffraction SEM: Scanning electron microscope TEM: Transmission electron microscope FTIR: Fourier-transform infrared spectroscopy TG: Thermogravimetry DSC: Differential scanning calorimetric AFM: Atomic force microscopy NMR: Nuclear magnetic resonance TMA: Thermal mechanical analysis DMTA: Dynamic Mechanical Thermal Analysis TMA: Thermomechanical Analysis CTE: Thermal expansion NPs: Nanoparticles EPR: Enhanced permeability and retention PMMC: Polymer matrix nanocomposites MMNC: Metal matrix nanocomposites CMNC: Ceramic matrix nanocomposites Ni: Nickle Cu: Copper Ti: Titanium Mg: Magnesium Al: Aluminum HDPE: High-density polyethylene UV: Ultraviolet IR: Infrared spectroscopy COOH: Carboxylic acid TiO 2 : Titanium dioxide NaOH: Sodium hydroxide NH 3 : Ammonia NH 4 OH: Ammonium hydroxide Na 2 CO 3 : Sodium carbonate Al 2 O 3 /SiC: Aluminum oxide/silicon carbide Si 3 N 4 /SiC: Silicon nitride/silicon carbide TiN: Titanium nitride TiC: Titanium carbide TiO 2 : Titanium dioxide ZrO 2 : Zirconium dioxide Cr 3 C 2 : Chromium carbide YAG: Yttrium aluminum garnet ZrO 2 /SiO 2 : zirconium dioxide/silicon dioxide SHS: Self-propagating high-temperature Synthesis CS: Combustion Synthesis TiN/Si 3 N 4 : Titanium nitride/silicon nitride ZrSiO 4 : Zirconium silicate C: Carbon B: Boron NaCl: Sodium chloride Nm: Nanometer m: Meter MWCNT-/PVA: Multi-walled carbon nanotube and polyvinyl alcohol DGEBA: Diglycidyl ether of bisphenol A PMMA: Polymethyl methacrylate HBP: Hyperbranched aromatic polyamide LDPE: Low-density polyethylene PVDF: polyvinylidene fluoride 2E-4MI: 2-Ethyl-4methylimidazole PANI: Polyaniline MMT: Montmorillonite BaF2: Barium Fluoride BaTiO 3 : Barium Titanate BiFeO 3 : Bismuth Ferrite CCTO: Calcium copper titanate oxide XLPE: Cross-linked polyethylene DMD: Disintegrated Melt Deposition PM: Powder Metallurgy MW: Microwave energy Ag/Au: Silver/gold Ni/PSZ and Ni/YSZ: nickel/partially stabilized zirconia and nickel/yttria-stabilized zirconia -Fe: Alpha iron Fe 3 O 4 : Iron (II, III) oxide Cu/Nb: Copper/niobium Al/AlN: Aluminum/Aluminum nitride PP: Polypropylene HIPS: High-impact polystyrene NDDS: Nanocomposite drug delivery systems FR: Folate receptors TfRs: Transferrin receptors v3: Integrins P-gp: P-glycoprotein MDR: Multidrug resistance GLUTs: Glucose Transporters DNA: Deoxyribonucleic acid HDACs: Histone Deacetylases MMPs: Matrix metalloproteinases GSH: Glutathione TLRs: Toll-like Receptors TME: Tumor Microenvironment VEGF: Vascular Endothelial Growth Factor TAMs: Tumor-associated Macrophages AM: Additive manufacturing GNPs: Gold nanoparticles PFA: Poly furfuryl alcohol TFN: Thin film nanocomposites IINS: Inelastic incoherent neutron scattering BF: Bright field SSC: Semi-Solid Casting References Tiwari G, Tiwari R, Bannerjee S et al (2012) Drug delivery systems: an updated review

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Fexinidazole has shown promise as a short-course oral therapy for various forms of leishmaniasis ( Nanoparticle formulations of Amphotericin B, including topical options, are being trialed for safer, localized treatment of CL lesions ( 7 Emerging drug targets in Leishmania Recent advances in molecular and cellular biology have identified several promising drug targets that could pave the way for novel therapeutic interventions (Jain et al., 2022)

[DOI] [PMC free article] [PubMed] [Google Scholar] 164.Maher J, Yamamoto M