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Thats because one of the breakdown products of caffeine is methyluric acid, and that can add to the bodys uric acid burden.235 In fact, allopurinol, the drug that is used to treat gout, works by inhibiting the enzyme that converts methylxanthine (a caffeine metabolite) to methyl-uric acid.236 Now, besides an inherited tendency to accumulate uric acid, liver disease significantly increases the likelihood that caffeine will contribute to gout.237 If you remember that the liver is responsible for the entire chain of breakdown steps in the detoxification of caffeine, this is not surprising
Nitric Oxide-Biol Chem
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