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laboratory tests including: radiographs (X-rays) indicating joint damage elevated inflammatory markers erythrocyte sedimentation rate (ESR) C-reactive protein (CRP) autoantibodies (rheumatoid factor or RF) anti-cyclic citrullinated peptide antibodies (anti-CCP) Inflammatory responses increase the proportion of fibrinogen in the blood, causing red blood cells to stick to each other, and this increases the rate at which red blood cells sediment in solution

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doi: 10.3389/fimmu.2023.1211231 110