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Smoking can attenuate negative symptoms by reducing dopamine degradation and enhancing the effects of nicotine-mediated dopamine release in male SCZ patients, particularly in the inferior prefrontal cortex circuit 40,46,47,48,49

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5 Figure 1.1 Diversity of e-cigarette products Up until recently, the existing evidence suggested that e-cigarette vapors were less harmful to humans' health than cigarette smoke, and may substantially reduce exposure to toxic chemicals among smokers who are unwilling to quit