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The progression from inflammation to fibrosis is primarily mediated by hepatic stellate cell (HSC) activation, which involves two core mechanisms: the Transforming Growth Factor-beta 1 (TGF-1) - Mothers Against Decapentaplegic Homolog 3 (Smad3) pathway and Platelet-Derived Growth Factor (PDGF) -driven epithelial-mesenchymal transition (EMT) 52 , Furthermore, Wnt ligands released by apoptotic bodies promote HSC proliferation through -catenin nuclear translocation 53

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209 Moreover, psychiatric disorders including depression and schizophrenia, which are related to postnatal environmental factors, are also intricately linked with epigenetics

This study was designed to test whether AOD9604 could damage DNA or cause genetic mutationsimportant safety questions for any compound being considered for human use