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Key Factors That Influence Recovery Severity of deficiency: Lower levels may take longer to correct

More refined studies (ATAC-seq, ChIP-seq H3K27ac) map activated enhancers and involved transcription factors (CREB, MEF2)

Additionally, Yamasaki et al reported that miR-146a is highly expressed in OA cartilage with low Mankin scores, and IL-1 can enhance its expression, indicating a potential role in OA-associated inflammatory responses

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