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Peer review Peer review information Nature Communications thanks Toni Giorgino and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Vit B12 status is also considered as a modulating factor of the phenotypic expression of PD as recent data have intriguingly suggested a potential role of Vit B12 deficiency in motor progression in PD assessed using the Unified Parkinsons Disease Rating Scale (UPDRS) and the ambulatory capacity score and the worsening of cognitive dysfunction evaluated via the mini-mental status examination (MMSE) (Christine et al

Store the lyophilized powder at -20C in a sealed container away from light and moisture