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In addition, citrulline, a major precursor for endogenous arginine, supplementation has been shown to restore systemic arginine levels, improve airway NO production, and asthma control in individuals with obesity-related asthma [124]
The results of a sequential supplementation trial in 53 men and women indicated that after optimization of folate status with folic acid supplements, vitamin B 12 became the major determinant of plasma homocysteine levels (30)
This treatment may be considered by patients dealing with joint discomfort, soft tissue concerns, or those interested in optimizing recovery after physical strain
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