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At the same time, the lycosin-I-gold nanoparticles had low sensitivity to non-tumor cells and could selectively accumulate at tumor sites through blood circulation in tumor-bearing mice model, but were non-toxic to normal mice

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Ligand-induced phosphorylation of the RTKs induces recruitment of the regulatory subunit of PI3K (p85) to the RTKs, relieving the inhibitory interaction with the catalytic subunit (p110) and resulting in activation

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