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Patients with diabetic kidney disease (DKD) exhibit pronounced gut microbiota dysbiosis, characterized by decreased abundance of commensal bacteria and increased prevalence of uremic toxin-producing bacteria (98) demonstrated that Roseburia intestinalis was significantly decreased while Bacteroides stercoris was markedly increased in the gut of biopsy-proven diabetic nephropathy patients, and this dysbiosis was closely correlated with parameters of lipid metabolism, glucose metabolism, and renal function

As shown in Figure S7 , the niclosamide UV/Vis spectra from 25uM to 300uM all show the characteristic double peak profile at this pH of 9.3, with max maxima at 333nm and 377nm, although the maximum in aqueous pH 9.3 buffer was closer to 335nm