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SIRT1 targets both histone and non-histone substrates, including histones (e.g., H3K9, H4K16 31 ) and transcriptional regulators such as p53, 32 FOXO1/3a, 33 PGC-1, 34 LKB1, 35 and NF-B p65, 36 thereby contributing to epigenetic regulation and broader cellular functions

PMID: 35367271 Int J NanomedicineNanoparticle-modified chitosan-agarose-gelatin scaffold for sustained release of SDF-1 and BMP-2

Among the most noticeable are nasolabial folds and marionette lines (also known as puppet lines), which can make the face appear tired or even sad