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This route is particularly relevant for gastrointestinal applications

IDH1 is found primarily in the cytosol and the peroxisomes

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For example, in certain lung pathophysiological conditions, oxygenation of terminal airways becomes uneven, such that this temporal and spatial variance in oxygen abundance essentially determines the survival of the lung cells via oxygen-dependent activation of cell regulators and genes critical to defending their structural/functional characteristics [5, 8, 10, 13, 14, 1618, 2123, 26, 27]