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Among different heavy metals, As is considered to be the most hazardous material not only in terms of plant growth and development but also due to its ill effects on human health

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Anti-estrogen-based endocrine therapies, such as the ER modulator Tamoxifen, ER degrader Fulvestrant, and the aromatase inhibitor Letrozole, have significantly enhanced the survival rates of patients with hormone receptor-positive (HR+) breast cancer [5]