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It is also strongly pro-angiogenic: in rat and endothelial-cell models it promoted new blood-vessel formation and blood-flow recovery by up-regulating the VEGFR2AkteNOS pathway[2]

In placebo-controlled trials for type 2 diabetes mellitus (T2DM), semaglutide injection 0.5 and 1 mg resulted in a mean increase in heart rate of 2 to 3 bpm